Evid Based Nurs 8:22 doi:10.1136/ebn.8.1.22
  • Treatment

Review: adding non-invasive positive pressure ventilation to usual care reduces treatment failure in respiratory failure

Non-invasive positive pressure ventilation (NPPV) plus usual care v usual care alone for respiratory failure precipitated by an acute exacerbation of chronic obstructive pulmonary disease*

Outcomes at 7.6–35 days Number of trials (n) Weighted event rates RRR (95% CI) NNT (CI)
NPPV plus usual care Usual care alone
*Treatment failure  =  a composite of all cause mortality, endotracheal intubation, and intolerance to the allocated treatment. Other abbreviations defined in glossary; weighted event rates, RRR, and CI calculated from data in article using a fixed effects model.
Treatment failure 8 (541) 19.7% 41.7% 52% (37 to 63) 5 (4 to 7)
All cause mortality 10 (622) 10.8% 20.8% 48% (24 to 65) 10 (7 to 25)
Endotracheal intubation 14 (758) 16.5% 40.5% 59% (47 to 67) 5 (4 to 6)

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