Review: adding non-invasive positive pressure ventilation to usual care reduces treatment failure in respiratory failure
Q In patients with respiratory failure precipitated by an acute exacerbation of chronic obstructive pulmonary disease (COPD), is non-invasive positive pressure ventilation (NPPV) plus usual care more effective than usual care alone for reducing rates of treatment failure, all cause mortality, and endotracheal intubation?
Cochrane Airways Group randomised controlled trials (RCTs) register, Medline, CINAHL, EMBASE/Excerpta Medica, and online respiratory journal databases (all up to April 2004); bibliographies of selected RCTs; and researchers in the field.
Study selection and assessment:
RCTs that compared usual care (including supplemental oxygen, antibiotics, bronchodilators, steroids, and respiratory stimulants) plus NPPV (applied by nasal or face mask) with usual care alone in adults with respiratory failure precipitated by an acute exacerbation of COPD. …