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Evid Based Nurs 8:18 doi:10.1136/ebn.8.1.18
  • Treatment

Review: chemotherapy plus supportive care improves survival and quality of life in advanced or metastatic gastrointestinal cancer more than supportive care alone

Chemotherapy plus supportive care (SC) v SC alone for patients with gastrointestinal cancer*

Patients’ conditions Number of patients Comparison Survival p Value
*CR  =  colorectal; CHT  =  chemotherapy; combination CHT  =  5-FU, leucovorin, and cisplatin; ELF  =  5-FU, leucovorin, and etoposide; FLv  =  5-FU and leucovorin.
†Patients could receive SC.
‡Significant only after correction for imbalances in pretreatment characteristics.
Advanced CR and stomach cancer refractory to CHT 107 Octreotide† v SC 20 v 11 weeks <0.0001
Metastatic CR cancer that progressed within 6 months of treatment with fluorouracil 279 Irinotecan plus SC v SC 9.2 v 6.5 months 0.0001
Previously untreated, inoperable, locally recurrent or metastatic CR cancer 36 Combination CHT plus SC v SC 11 v 5 months 0.006
Advanced, surgically incurable stomach cancer 61 ELF or FLv plus SC v SC 8 v 5 months 0.003‡

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