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Evid Based Nurs 8:14 doi:10.1136/ebn.8.1.14
  • Treatment

Review: long term use of common medications for asthma reduces exacerbations in adults

Effectiveness of common pharmacological medications for asthma in adults at 3–39 months*

Outcome Comparison Number of trials (n) RRR (95% CI)
*ICSs  =  inhaled corticosteroids; SABAs  =  short acting β2 agonists; LABAs  =  long acting β2 agonists; LPMs/RAs  =  leukotriene pathway modifiers/receptor antagonists. Other abbreviations defined in glossary; RRR and CI calculated from data in article.
†Calculated using a random effects model.
Rate of exacerbations ICSs v placebo or SABAs 11 (9418) 54% (38 to 66)†
LABAs v placebo 9 (2854) 25% (12 to 36)
ICSs plus LABAs v ICSs 7 (3886) 26% (9 to 39)
ICSs plus LABAs v doubled dosage of ICSs 10 (5680) 14% (4 to 24)
LPMs/RAs v placebo 7 (4375) 41% (29 to 51)
ICSs plus anti-IgE antibodies v ICSs 3 (1388) 45% (34 to 55)

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