|Outcomes||Number of trials (n)||Weighted RR point estimate (95% CI)†|
|*RR = relative risk, CI = confidence interval.|
|†For pain, RRs>1 indicate a greater likelihood of achieving >50% maximum pain relief with ibuprofen than with paracetamol. For harm, RRs>1 indicate a greater likelihood of harm with ibuprofen than with paracetamol.|
|§An effect size of 0 represents equal effectiveness of the drugs for reducing fever; effect sizes >0 represent superiority of ibuprofen over paracetamol.|
|Pain relief at 2 hours||3 (186)||1.14 (0.82 to 1.58)‡|
|Pain relief at 4 hours||3 (186)||1.11 (0.89 to 1.38)‡|
|Minor harm at median 48 hours||17 (1820)||0.96 (0.68 to 1.36)‡|
|Major harm at median 48 hours||17 (1813)||1.00 (0.55 to 1.82)‡|
|Weighted effect size point estimate (CI)§|
|Fever reduction at 2 hours||10 (1078)||0.19 (0.05 to 0.33)|
|Fever reduction at 4 hours||10 (1078)||0.31 (0.19 to 0.44)|
|Fever reduction at 6 hours||10 (1078)||0.33 (0.19 to 0.47)|
Review: no evidence exists that paracetamol and ibuprofen differ for short term pain relief or safety in children, but ibuprofen more effectively reduces fever
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