Evid Based Nurs 7:121 doi:10.1136/ebn.7.4.121
  • Causation

Routine childhood vaccinations did not increase the risk of incident type 1 diabetes in Danish children

Association between routinely administered childhood vaccines and incident type 1 diabetes mellitus in Danish children at a mean age of 6.4 years*

Vaccine Rate ratio (95% CI)
All children† Children with ⩾1 sibling with type 1 diabetes‡
*Rate ratios (comparing rates in children vaccinated with ⩾1 dose v unvaccinated) show that all associations are not significant; CI defined in glossary.
†Rate ratios adjusted for age, calendar period, and sex.
‡Rate ratios adjusted for age, calendar period, sex, and number of siblings.
Haemophilus influenza type b 0.91 (0.74 to 1.12) 1.38 (0.58 to 3.31)
Diphtheria, tetanus, and inactivated poliovirus 1.02 (0.75 to 1.37) 3.03 (0.41 to 22.63)
Diphtheria, tetanus, acellular pertussis, and inactivated poliovirus 0.96 (0.71 to 1.30) 1.36 (0.50 to 3.70
Whole cell pertussis 1.06 (0.80 to 1.40) 1.68 (0.39 to 7.19)
Measles, mumps, and rubella 1.14 (0.90 to 1.45) 0.86 (0.34 to 2.14)
Oral poliovirus 1.08 (0.74 to 1.57) 2.01 (0.46 to 8.71)

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