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Evid Based Nurs 7:120 doi:10.1136/ebn.7.4.120
  • Prognosis

Severity of cognitive impairment at initial diagnosis of Alzheimer’s disease was the strongest predictor of survival

Prognostic factors for mortality in community dwelling patients with newly diagnosed Alzheimer’s disease*

Prognostic factor Median years of survival† Hazard ratio (95% CI)‡
*MMSE  =  Mini Mental State Examination; DRS  =  Dementia Rating Scale; other abbreviations defined in glossary.
†Time until death when 50% of patients died.
‡Independent prognostic factors based on proportional hazards model adjusted for age at diagnosis, sex, and ethnicity.
MMSE score ⩽17 3.6 2.58 (1.88 to 3.53)
DRS score 5.5–17 3.2 2.15 (1.62 to 2.84)
Frontal lobe release signs 4.6 1.26 (1.03 to 1.54)
Gait disturbance 3.5 1.50 (1.20 to 1.87)
History of falls 4.3 1.30 (1.05 to 1.60)
Ischaemic heart disease 4.1 1.30 (1.05 to 1.61)
Congestive heart failure 3.0 1.48 (1.10 to 1.99)
Diabetes 3.8 1.87 (1.34 to 2.61)

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