Severity of cognitive impairment at initial diagnosis of Alzheimer’s disease was the strongest predictor of survival
Q What is the course of disease (specifically life expectancy) after an initial diagnosis of Alzheimer’s disease (AD) in community dwelling patients? Which variables are associated with survival?
inception cohort with mean follow up of 5.2 years (range 0.2–14 y).
a health maintenance organisation in Seattle, Washington, USA.
521 patients who were >60 years of age (65% women, 89% white) and newly diagnosed with possible or probable AD based on criteria of DSM-III-R (dementia) and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer’s Disease and Related Disorders Association (probable or possible AD).
baseline severity of AD (Mini-Mental State Examination [MMSE] score and Dementia Rating Scale score [DRS]); psychiatric symptoms of paranoia …