Evid Based Nurs 7:106 doi:10.1136/ebn.7.4.106
  • Treatment

Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children

 Q Are selective serotonin reuptake inhibitors (SSRIs) safe for treating depression in children?


GraphicData sources:

Medline, CINAHL, EMBASE/Excerpta Medica, and PsycINFO (to April 2003); Cochrane Library; reference lists; tables of contents; previous systematic reviews; Guideline Development Group information; and written requests to experts.

GraphicStudy selection and assessment:

English language RCTs (or RCTs with English abstracts) that compared SSRIs with placebo in children (5–18 y) with depression; had adequate blinding, concealed allocation, and description of withdrawals; and were published in peer reviewed journals or reviewed in a report by the Committee on Safety of Medicines.


adverse events, remission, response, and mean depression level.


5 published and 9 unpublished RCTs were reviewed. Fluoxetine …

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