Review: long acting β2 agonists and inhaled corticosteroids reduce exacerbations in chronic obstructive pulmonary disease
- pulmonary disease (chronic obstructive)
- adrenergic beta-agonists
- bronchodilator agents
- cholinergic antagonists
Q What are the effects of common treatments for chronic obstructive pulmonary disease (COPD) on patient outcomes?
Medline (1980 to 1 May 2002), Cochrane Database of Systematic Reviews, bibliographies of published articles, and experts.
Study selection and assessment:
English language randomised controlled trials (RCTs) with ⩾3 months of follow up in adults with COPD that assessed long acting (LA) β2 agonists (β2As); LA inhaled anticholinergics (tiotropium); combined short acting (SA) β2As and SA anticholinergics; inhaled corticosteroids; combined inhaled corticosteroids and LAβ2As; pulmonary rehabilitation (with ⩾6 wks follow up); long term nocturnal non-invasive mechanical ventilation; domiciliary O …