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Evid Based Nurs 7:84 doi:10.1136/ebn.7.3.84
  • Treatment

Review: single dose, oral paracetamol reduces moderate to severe postoperative pain

Single dose paracetamol v placebo for ⩾50% pain relief within 4–6 hours after surgery*

Dosage of paracetamol Number of trials (n) Event rates RBI (95% CI) NNT (CI)
Paracetamol Placebo
*Abbreviations defined in glossary; RBI calculated from relative benefit data in article.
†Information provided by author.
325 mg 1 (100) 69% 43% 60% (10 to 130) 4 (3 to 14)
500 mg 6 (561) 61% 32% 90% (60 to 130) 4 (3 to 5)
600/650 mg 19 (1886) 38% 16% 140% (100 to 180) 5 (4 to 6)
975/1000 mg 23 {2759}† 46% 20% 150% (120 to 180) 4 (4 to 5)
1500 mg 1 (65) 65% 39% 70% (20 to 140) 4 (3 to 10)

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