Evid Based Nurs 7:82 doi:10.1136/ebn.7.3.82
  • Treatment

Cholesterol lowering with simvastatin reduced stroke in patients with, or at risk of, vascular disease

Simvastatin v placebo in patients at high risk of vascular disease*

Outcomes at 5 years Simvastatin Placebo RRR (95% CI) NNT (CI)
*Abbreviations defined in glossary; NNT and CI calculated from control event rate and rate ratio reported in article.
†Non-fatal myocardial infarction or coronary death, stroke, or revascularisation procedure.
≥1 major vascular event† 20% 25% 24% (19 to 28) 17 (15 to 21)
≥1 stroke 4.3% 5.7% 25% (15 to 34) 71 (52 to 117)
≥1 ischaemic stroke 2.8% 4.0% 30% (19 to 40) 84 (63 to 133)

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