Evid Based Nurs 7:82 doi:10.1136/ebn.7.3.82
  • Treatment

Cholesterol lowering with simvastatin reduced stroke in patients with, or at risk of, vascular disease

 Q Does cholesterol lowering with simvastatin reduce the incidence of stroke in patients with, or at high risk of, vascular disease?



randomised controlled trial (Heart Protection Study [HPS]).




blinded {patients, clinicians, and data monitoring committee}*.

GraphicFollow up period:

5 years.


{69 hospitals in the UK}*.


20 536 patients (mean age 64 y, 75% men) who had non-fasting blood total cholesterol concentrations ⩾3.5 mmol/l (135 mg/dl) and a medical history of cerebrovascular disease, coronary disease, other occlusive arterial disease, diabetes, or were men ⩾65 years with treated hypertension. Exclusion criteria: clear indication or non-indication for statin therapy; stroke, myocardial infarction, or admission for …

No Related Web Pages

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article