Evid Based Nurs 7:82 doi:10.1136/ebn.7.3.82
  • Treatment

Cholesterol lowering with simvastatin reduced stroke in patients with, or at risk of, vascular disease

 Q Does cholesterol lowering with simvastatin reduce the incidence of stroke in patients with, or at high risk of, vascular disease?



randomised controlled trial (Heart Protection Study [HPS]).




blinded {patients, clinicians, and data monitoring committee}*.

GraphicFollow up period:

5 years.


{69 hospitals in the UK}*.


20 536 patients (mean age 64 y, 75% men) who had non-fasting blood total cholesterol concentrations ⩾3.5 mmol/l (135 mg/dl) and a medical history of cerebrovascular disease, coronary disease, other occlusive arterial disease, diabetes, or were men ⩾65 years with treated hypertension. Exclusion criteria: clear indication or non-indication for statin therapy; stroke, myocardial infarction, or admission for …

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