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Evid Based Nurs 7:49 doi:10.1136/ebn.7.2.49
  • Treatment

Oestrogen plus progestogen did not prevent cardiovascular disease in postmenopausal women

Oestrogen plus progestogen v placebo in postmenopausal women*

Annualised percentage developing coronary heart disease (CHD)
Outcomes at mean 5.3 years Oestrogen plus progestogen Placebo Adjusted hazard ratio (95% CI)
*CI defined in glossary. Hazard ratio adjusted for the presence or absence of previous coronary revascularization and sequential monitoring.
†Not significant.
All CHD 0.39% 0.33% 1.24 (0.97 to 1.60)†
Non-fatal myocardial infarction (MI) 0.31% 0.25% 1.28 (0.96 to 1.70)†
Nonfatal MI (excluding silent MI) 0.31% 0.24% 1.30 (0.97 to 1.74)†
Death caused by CHD 0.08% 0.08% 1.10 (0.65 to 1.89)†

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