Evid Based Nurs 7:47 doi:10.1136/ebn.7.2.47
  • Treatment

Selective decontamination of the digestive tract reduced intensive care unit and hospital mortality in adults

 Q Does selective decontamination of the digestive tract (SDD) reduce mortality and acquisition of resistant bacteria in adult patients in the intensive care unit (ICU)?



randomised controlled trial.





GraphicFollow up period:

to hospital discharge.


an ICU at an academic medical centre in Amsterdam, The Netherlands.


1090 patients >18 years of age (mean age 60 y, 59% men; based on n = 934), who had an expected duration of mechanical ventilation ⩾48 hours, an expected ICU stay of ⩾72 hours, or both. Exclusion criteria: previous ICU admission within 3 months, known hypersensitivity to study medication, pregnancy, perceived imminent death, and participation in another study.


537 patients were allocated to the SDD unit, and received 0.5 g of an oral paste (2% polymyxin E, 2% tobramycin, and 2% amphotericin B), applied to the buccal …

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