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Evid Based Nurs 7:41 doi:10.1136/ebn.7.2.41
  • Treatment

Higher oxygen saturation targets did not improve growth and neurodevelopment in extremely preterm infants


 
 Q Does maintenance of higher oxygen saturation (SpO2) targets (95–98%) improve growth and neurodevelopment compared with standard targets (91–94%) in extremely preterm infants dependent on supplemental oxygen?

METHODS:

GraphicDesign:

randomised controlled trial.

GraphicAllocation:

concealed.

GraphicBlinding:

blinded {patients, healthcare providers, data collectors, outcome assessors, monitoring committee}*.

GraphicFollow up period:

corrected age (chronologic age plus number of wks of prematurity) at 12 months.

GraphicSetting:

8 tertiary perinatal centres in Sydney, Australia.

GraphicPatients:

358 infants (mean age 26.5 wks, 53% boys) who were born at <30 weeks gestational age and remained dependent on supplemental oxygen at 32 weeks postmenstrual age (PA). Exclusion criteria: major congenital abnormalities; major surgery or severe intracranial disorder diagnosed at <32 weeks PA; and multiple births with ⩾3 eligible infants.

GraphicInterventions:

infants were stratified by hospital, singleton or multiple birth, and …

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