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Treatment
Lifestyle recommendations reduced blood pressure in patients with above optimal blood pressure

https://doi.org/10.1136/ebn.7.1.18

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    Appel LJ, Champagne CM, Harsha DW, et al. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA 2003;289:2083–93.OpenUrlCrossRefPubMedWeb of Science

    Q In patients with above optimal blood pressure (BP), what is the relative effectiveness of 2 behavioural interventions (established lifestyle recommendations [ELR] and ELR plus the Dietary Approaches to Stop Hypertension [DASH] diet) compared with advice only?

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded (data collectors).

    Embedded ImageFollow up period:

    6 months.

    Embedded ImageSetting:

    4 clinical centres in Maryland, Louisiana, North Carolina, and Oregon, USA.

    Embedded ImagePatients:

    810 generally healthy adults who were ⩾25 years of age (mean age 50 y, 62% women), had above optimal BP (mean systolic BP 120–159 mm Hg and diastolic BP 80–95 mm Hg across 3 screening visits), were not taking …

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    Footnotes

    • A modified version of this abstract appears in ACP Journal Club and Evidence-Based Medicine.

    • For correspondence: Dr L J Appel, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA. lappeljhmi.edu

    • Source of funding: National Institutes of Health.