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Evid Based Nurs 7:16 doi:10.1136/ebn.7.1.16
  • Treatment

Oestrogen plus progestogen increased risk of breast cancer in postmenopausal women


 
 Q In postmenopausal women, does oestrogen plus progestogen hormone therapy increase the risk of abnormal mammographic results and diagnosis of breast cancer?

METHODS

GraphicDesign:

randomised, placebo controlled trial (Women’s Health Initiative).

GraphicAllocation:

concealed.

GraphicBlinding:

blinded (clinicians, participants, data collectors, outcome assessors, and monitoring committee).

GraphicFollow up period:

mean 5.6 years.

GraphicSetting:

40 US clinical centres.

GraphicPatients:

16 608 postmenopausal women who were 50–79 years of age (mean age 63 y). Exclusion criteria: previous hysterectomy, breast cancer, or probable survival <3 years.

GraphicInterventions:

1 daily tablet of conjugated equine oestrogen, 0.625 mg, and medroxyprogesterone acetate, 2.5 mg (Prempro, Wyeth Ayerst, Philadelphia, PA, USA) (n = 8506) or placebo (n = 8102).

GraphicOutcomes:

incidence of breast cancer (total, invasive, and in situ) and …

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