Oral vitamin D3 supplementation reduced fractures in community dwelling elderly people
QUESTION: Does oral vitamin D3 (cholecalciferol) supplementation reduce the incidence of fractures in community dwelling elderly people 65–85 years of age?
Randomised (unclear allocation concealment), blinded (participants and clinicians), placebo controlled trial with 5 years of follow up.
Community based study with participants recruited from the British Doctors Study register and a general practice register in Suffolk, UK.
2686 elderly people 65–85 years of age (mean age 75 y, 76% men) who were living in the general community. Exclusion criteria included current use of vitamin D3 supplements and contraindications to vitamin D3 supplementation such as a history of renal stones, sarcoidosis, or malignancy.
Participants, stratified by age and sex, were allocated to …