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Evid Based Nurs 6:110 doi:10.1136/ebn.6.4.110
  • Treatment

An intensive, target driven intervention reduced cardiovascular and microvascular events in patients with type 2 diabetes and microalbuminuria

Intensive v conventional treatment in type 2 diabetes and microalbuminuria†

Outcomes (mean 7.8 y follow up) Intensive Conventional Adjusted HR (95% CI) NNT (CI)
Composite endpoint‡ 24% 44% 0.47 (0.22 to 0.74) 5 (3 to 19)
RRR (CI) NNT (CI)
†HR = hazard ratio. Other abbreviations defined in glossary; RRR, NNT, and CI calculated from data provided by author. HR adjusted for baseline characteristics. ‡Composite endpoint of various cardiovascular events.
Diabetic nephropathy 20% 39% 48% (15 to 69) 6 (4 to 22)
Retinopathy (developed or progressed) 48% 64% 25% (1.5 to 44) 7 (4 to 125)
Autonomic neuropathy 30% 54% 44% (18 to 63) 5 (3 to 12)

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