Evid Based Nurs 6:89 doi:10.1136/ebn.6.3.89
  • Causation

Measles, mumps, and rubella vaccine was not associated with autism in children

 QUESTION: Is the measles, mumps, and rubella (MMR) vaccine associated with autism in children?


Population based cohort study with data obtained by database linkage.




537 303 children (51% boys).

Assessment of risk factors

MMR vaccination status was obtained from the Danish National Board of Health (compiled by general practitioner reports). Data on birth weight, sex, gestational age, family socioeconomic status, and mother’s education were also collected.

Main outcome measures

Children’s autism status was obtained from the Danish Psychiatric Central Register; diagnoses of autistic disorder or another autistic spectrum disorder were assigned by specialists in child psychiatry. If a child was diagnosed with both autistic disorder and ≥1 other autistic spectrum disorder, the diagnosis was classified as autistic disorder.

Main results

The 537 303 children had follow up for a total of 2 129 …

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