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Evid Based Nurs 6:82 doi:10.1136/ebn.6.3.82
  • Treatment

Review: heparin and mechanical pumping devices reduce deep venous thrombosis after surgery for hip fracture

Heparin (unfractionated or low molecular weight) and mechanical methods v control after hip fracture surgery in elderly patients*

Weighted event rates
Outcomes Number of studies (patients) Heparin Control RRR (95% CI) NNT (CI)
Any DVT 13 (993) 25% 42% 40% (29 to 50) 6 (5 to 9)
Proximal DVT 7 (407) 8.6% 21% 55% (27 to 72) 9 (6 to 17)
Distal DVT 6 (357) 25% 38% 35% (11 to 53) 8 (5 to 25)
Mechanical methods Control
*Abbreviations defined in glossary; experimental event rates, RRR, NNT, and CI calculated from data in article. Follow up ranged from 4 days to 6 months. Meta-analyses were done using a fixed effects model.
Any DVT 5 (450) 6.7% 23% 69% (49 to 81) 7 (5 to 10)
Proximal DVT 4 (414) 2.4% 12% 78% (47 to 90) 10 (7 to 20)
Distal DVT 2 (103) 19% 42% 55% (15 to 77) 5 (3 to 17)
PE 5 (487) 2.4% 6.4% 60% (4 to 83) 25 (13 to undefined)

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