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Evid Based Nurs 6:80 doi:10.1136/ebn.6.3.80
  • Treatment

Digoxin increased risk of death in women, but not men, with heart failure

Digoxin v placebo for heart failure (HF) in men and women

Outcomes at ≤48 months Sex Digitalis Placebo Adjusted RRR (95% CI) Adjusted NNT (CI)
All cause mortality Men 35.2% 36.9% 6% (−2 to 12) Not significant
Cardiovascular death 30.5% 31.1% 3% (−5 to 11) Not significant
Death from worsening HF 11.4% 13.6% 20% (7 to 30) 38 (25 to 99)
Hospital admission for worsening HF 25.8% 34.7% 29% (23 to 35) 10 (9 to 13)
Adjusted RRI (CI) Adjusted NNH (CI)
Hospital admission for other causes 39.9% 35.0% 13% (6 to 21) 22 (14 to 52)
All cause mortality Women 33.1% 28.9% 19% (2 to 36) 19 (10 to 207)
Cardiovascular death 27.8% 24.1% 20% (2 to 42) 21 (10 to 240)
Death from worsening HF 12.4% 11.9% 16% (−12 to 51) Not significant
Hospital admission for other causes 35.9% 32.2% 12% (−2 to 28) Not significant
Adjusted RRR (CI) Adjusted NNT
‡Abbreviations defined in glossary; RRR, RRI, NNT, NNH, and CI calculated from control event rates and adjusted hazard ratios in article.
Hospital admission for worsening HF 30.2% 34.4% 11 (−3 to 24) Not significant

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