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Evid Based Nurs 6:49 doi:10.1136/ebn.6.2.49
  • Treatment

Review: anticholinergic drugs improve symptoms but increase dry mouth in adults with overactive bladder syndrome

Parallel arm studies of anticholinergic drugs v placebo for overactive bladder syndrome in adults at 12 days to 12 weeks*

Weighted event rates
Outcomes Anticholinergic drugs Placebo RBI (95% CI) NNT (CI)
Self reported cure or improvement (8 studies) 63% 45% 41% (29 to 54) 6 (5 to 8)
RRI (CI) NNH (CI)
Dry mouth (20 studies) 36% 15% 138 (70 to 232) 5 (4 to 7)
Outcomes Weighted mean difference (CI)
*Abbreviations defined in glossary; RBI, RRI, NNT, NNH, and CI calculated from data in article.
Number of leakage episodes in 24 hours (9 studies) −0.56 (–0.73 to –0.39)
Number of micturitions in 24 hours (8 studies) −0.59 (–0.83 to –0.36)
Maximum cystometric volume (ml) (12 studies) 54.3 (43.0 to 65.7)
Volume at first contraction (ml) (9 studies) 52.3 (37.5 to 67.1)
Residual volume (ml) (11 studies) 4.1 (0.73 to 7.4)

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