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Evid Based Nurs 6:47 doi:10.1136/ebn.6.2.47
  • Treatment

Supplementation with key nutrients reduced postoperative infections and length of hospital stay after gastrointestinal surgery


 
 QUESTION: In well nourished patients with cancer of the gastrointestinal (GI) tract, is preoperative supplementation (PSUP) or PSUP plus postoperative enteral nutrition (POEN) with key nutrients more effective than conventional treatment (COTR) for reducing postoperative infections and length of hospital stay?

Design

Randomised (allocation concealed), unblinded, controlled trial with 30 days of follow up after hospital discharge.

Setting

Department of surgery, San Raffaele University, Milan, Italy.

Patients

305 patients (mean age 64 y, 54% men) who had histologically documented cancer of the GI tract and planned major elective surgery. Exclusion criteria included weight loss ≥10% (with respect to usual body weight) in the past 6 months, age <18 years, and hepatic dysfunction (Child-Pugh class >B). Follow up was 100%.

Intervention

Patients were allocated to PSUP (n=102), POEN (n=101), or COTR (n=102). Before surgery, patients in the PSUP …

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