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Evid Based Nurs 6:20 doi:10.1136/ebn.6.1.20
  • Treatment

Oestrogen plus progestin increased coronary heart disease and breast cancer in postmenopausal women

Oestrogen plus progestin (Oest + Prog) v placebo for postmenopausal women*

Event rates per patient-year
Unfavourable outcomes Oest + Prog Placebo RRI (95%CI) NNH (CI)
All cardiovascular disease 1.57% 1.32% 22% (9 to 36) 348 (213 to 848)
Coronary heart disease 0.37% 0.30% 29% (2 to 63) 1152 (531 to 16 693)
Stroke 0.29% 0.21% 41% (7 to 85) 1164 (562 to 6811)
Venous thromboembolism 0.34% 0.16% 111% (58 to 182) 565 (345 to 1079)
Invasive breast cancer 0.38% 0.30% 26% (0 to 59) 1285 (567 to infinity)
Favourable outcomes RRR (CI) NNT (CI)
*Abbreviations defined in glossary; RRI, RRR, NNH, NNT, and CI calculated from hazard ratios, CIs, and control event rates in article.
Vertebral fracture 0.09% 0.15% 34% (2 to 56) 1962 (1191 to 33 358)
Hip fracture 0.10% 0.15% 34% (2 to 55) 1962 (1213 to 33 358)
Colorectal cancer 0.10% 0.16% 37% (8 to 57) 1691 (1097 to 7819)

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