Review: chlorhexidine gluconate is more effective than povidone-iodine for preventing vascular catheter related bloodstream infection
- catherisation (central venous)
- anti-infective agents (local)
QUESTION: Is chlorhexidine gluconate as effective as povidone-iodine for preventing vascular catheter related bloodstream infection (CRBI)?
Clinical trials in any language were identified by searching Medline (1966–2001), CINAHL (1982–2001), Doctoral Dissertation Abstracts (1861–2001), International Pharmaceutical Abstracts (1970–2001), EMBASE/Excerpta Medica, Lexis-Nexus, Web of Sciences, and the Cochrane Library; hand searching Index Medicus (1960–65) and scientific meeting programmes and proceedings; reviewing bibliographies of retrieved articles; and contacting the manufacturer of chlorhexidine gluconate, authors of relevant studies, and experts in the field.
Studies were included if they were randomised trials that compared any type of chlorhexidine gluconate solution with a povidone-iodine solution for vascular catheter site care, and outcomes included incidence of CRBI or catheter colonisation, with sufficient data to calculate risk ratios.
Data were independently extracted by 2 reviewers on …