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Evid Based Nurs 6:15 doi:10.1136/ebn.6.1.15
  • Treatment

Review: antibiotic treatment for 7–14 days reduces treatment failure in children with urinary tract infection

Long course (LC) (7–14 d) v short course (SC) (1 d or 3 d, or a single dose [SD]) antibiotic treatment for urinary tract infection in children at 1 to 10 days*

Outcomes NRCTs Comparison Weighted event rates RRR (95% CI) NNT (CI)
TF 12 LC v SC (overall) 9% v 16% 48% (18 to 67) 14 (8 to 61)
10 LC v SC (PLUTI only) 11% v 16% 42% (8 to 64) 18 (9 to 203)
7 LC v SD or 1 day 11% v 25% 61% (28 to 79) 7 (5 to 15)
5 LC v 3 day 9% v 12% 26% (−42 to 62) Not significant
Reinfection 4 LC v 3 day 7% v 8% 9% (−110 to 61) Not significant
RRI (CI) NNH (CI)
*NRCTs = number of randomised controlled trials; TF = treatment failure; PLUTI = patients with lower urinary tract infection. Other abbreviations defined in glossary; RRR, RRI, NNT, NNH, CI, and weighted event rates calculated from data supplied by author using a random effects model.
6 LC v SC (overall) 10% v8% 28% (−36 to 156) Not significant
5 LC v SC (PLUTI only) 14% v 10% 39% (−38 to 211) Not significant
2 LC v SD or 1 day 25% v 8% 165% (−10 to 681) Not significant

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