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QUESTION: In children with urinary tract infection (UTI), is a long course (LC) of antibiotic treatment more effective than a short course (SC) for preventing treatment failure or reinfection?
Data sources
Studies were identified by searching Medline and the Cochrane Library (all up to April 2001), reviewing bibliographies of relevant articles, and contacting experts in the field for any other published or unpublished studies.
Study selection
Studies published in English were selected if they were randomised controlled trials (RCTs) comparing SC with LC outpatient antibiotic treatment for acute UTI in children 0–18 years of age. Studies that were restricted to children with recurrent UTI or that included children with asymptomatic bacteriuria were excluded from the review.
Data extraction
2 reviewers independently extracted data on setting, sample size, …
Footnotes
For correspondence: Dr R Keren, Division of General Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA. keren{at}email.chop.edu
Source of funding: US Department of Health and Human Services.