Evid Based Nurs 6:14 doi:10.1136/ebn.6.1.14
  • Treatment

Mifepristone was more effective than the Yuzpe regimen for emergency contraception

 QUESTIONS: In women seeking emergency contraception, is low dose mifepristone more effective than the Yuzpe regimen in preventing pregnancies? Does it have fewer side effects and better patient acceptability?


Randomised (allocation concealed), unblinded, controlled trial. Women were followed up for 2 weeks after the expected next menstrual period. Women who were not pregnant were followed up until their next period.


A family planning clinic in Aberdeen, Scotland.


1000 women between 16 and 45 years of age seeking emergency contraception within 72 hours after an episode of unprotected sexual intercourse who had regular menstrual cycles (21–35 d), were certain about the dates of their last menstrual period, and were willing to abstain from further acts of unprotected intercourse during the menstrual cycle. Exclusion criteria were use of oral contraceptives or hepatic enzyme inducing drugs, chronic adrenal failure, long …

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