Evid Based Nurs 5:110 doi:10.1136/ebn.5.4.110
  • Treatment

Review: pentoxifylline with standard compression treatment improves healing of venous leg ulcers

Oral pentoxifylline (pent) v placebo for venous leg ulcers†

Outcomes Adjunctive compression treatment Number of studies (n) Pent Placebo RBI (95% CI) NNT (CI)
†Abbreviations defined in glossary; RBI, NNT, and CI calculated from data in article using a fixed effects model except ‡, which was based on a random effects model. Follow up times of individual studies ranged from 2−6 months.
Healing or significant improvement‡ With or without compression 8 (549) 60% 42% 49% (11 to 101) 6 (4 to 19)
Complete healing With compression 5 (447) 62% 47% 30% (10 to 54) 7 (5 to 18)
Complete healing or significant improvement Without compression 3 (102) 51% 21% 142% (34 to 335) 4 (3 to 8)

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