Evid Based Nurs 5:90 doi:10.1136/ebn.5.3.90
  • Clinical prediction guide

A simple risk index accurately predicted mortality in patients with ST elevation myocardial infarction

 QUESTION: Can a simple risk index based on 3 routinely collected variables accurately predict mortality in patients with ST elevation myocardial infarction (MI)?


Patient data from 3 multicentre randomised controlled trials were used for the development and validation of a risk index (Intravenous nPA for the Treatment of Infarcting Myocardium Early [InTIME II] Trial; and Thrombolysis and Thrombin Inhibition in Myocardial Infarction [TIMI] 9A and B trials).


>800 hospitals worldwide from the InTIME II trial for index development and {150 centres in the US, UK, Canada, Israel, and Germany}* from the TIMI 9A and B trials for index validation.


The development set comprised data from 13 253 patients who had ST elevation MI and were enrolled within 6 hours of symptom onset, and who did not have a history of cerebrovascular disease, systolic blood pressure (SBP) >180 mm Hg, diastolic blood pressure (DBP) >110 mm Hg, cardiogenic shock, or increased risk of severe bleeding. The validation set comprised data …

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