Effects of hormone therapy on health related quality of life in postmenopausal women with CAD differed according to presence of menopausal symptoms
QUESTION: Does hormone therapy (HT) improve health related quality of life (HRQL) in postmenopausal women with coronary artery disease (CAD)?
Design
Randomised {allocation concealed}*, blinded {patients, clinicians, and outcome assessors}* placebo controlled trial with follow up to 3 years.
Setting
Outpatient and community settings in 20 clinical centres in the US.
Patients
2763 postmenopausal women <80 years of age (mean age 67 y) with documented CAD (previous myocardial infarction [MI], >50% luminal narrowing of a major vessel on angiography, or a previous coronary revascularisation procedure). Exclusion criteria were MI or revascularisation procedure in the previous 6 months, previous hysterectomy, contraindications to HT, HT in the previous 3 months, or life threatening illness. 2762 patients (99.9%) were included in the analysis; 2246 (81%) had HRQL data for all time points (baseline, 4 mo, 1 y, and 3 y).
Intervention
1380 women …
