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Prone positioning for acute respiratory failure improved short term oxygenation but not survival

https://doi.org/10.1136/ebn.5.2.52

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    Gattinoni L, Tognoni G, Pesenti A, et al, for the Prone-Supine Study Group. Effect of prone positioning on the survival of patients with acute respiratory failure.N Engl J Med2001 Aug 23;345:568–73OpenUrlCrossRefPubMedWeb of Science

    QUESTION: Does prone positioning for ≥ 6 hours each day for 10 days improve survival of patients with acute lung injury or the acute respiratory distress syndrome (ARDS)?

    Design

    Randomised (allocation concealed), unblinded, controlled trial with 6 months of follow up.

    Setting

    28 intensive care units (ICUs) in Italy and 2 in Switzerland.

    Patients

    304 patients (mean age 58 y, 68% men) who were receiving mechanical ventilation and met the following modified criteria for acute lung injury or ARDS: ratio of partial pressure of arterial oxygen (PaO2) to fraction of inspired oxygen (FiO2) ≤ 200 with a positive end expiratory pressure (PEEP) ≥ 5 cm of water, or a PaO2:FiO2 ratio ≤ 300 with a PEEP ≥ 10 cm water; radiographic evidence of …

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