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Evid Based Nurs 5:42 doi:10.1136/ebn.5.2.42
  • Treatment

A 30 mg/kg loading dose of acetaminophen was more effective than a 15 mg/kg maintenance dose in febrile children

A 30 mg/kg loading dose of acetaminophen v a 15 mg/kg maintenance dose in febrile children*

Outcomes 30 mg/kg 15 mg/kg Mean difference (95% CI)
Time to obtain temperature < 38.5°C (min) 110.7 139.5 −28.8 (−66.5 to −8.9)
Maximum temperature decrease (°C) 2.3 1.8 0.5 (0.3 to 0.8)
Duration of rectal temperature < 38.5°C (min) 255.2 200.8 54.4 (14.7 to 94.2)
Outcome at 6 hours 30 mg/kg 15 mg/kg RRR (CI) NNT (CI)
*Abbreviations defined in glossary; RRR, NNT and CI calculated from data in article.
Received a temperature altering treatment 10% 26% 61% (10 to 83) 7 (4 to 52)

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