Evid Based Nurs 4:121 doi:10.1136/ebn.4.4.121
  • Treatment

Review: glucosamine is more effective than selected non-steroidal anti-inflammatory drugs and placebo for reducing pain and more effective than placebo for improving function in patients with osteoarthritis

Glucosamine (Glu) v placebo (pl) or selected non-steroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis*

Outcomes Comparison Number of studies (number of patients) Standardised mean difference (95% CI)
*Abbreviations defined in glossary; RBI, NNT, and CI calculated from data in article. Outcomes were analysed using either a random (†) or fixed (‡) effects model.§Not significant.
Pain Glu v NSAIDs 3 (292) 0.86 (0.58 to 1.14)‡
Glu v pl 7 (471) 1.40 (0.65 to 2.14)†
Function Glu v NSAIDs 2 (364) 0.32 (−0.28 to 0.92)†§
Glu v pl 3 (563) 0.63 (−0.04 to 1.29)†§
Weighted event rates (number of studies) RBI (95% CI) NNT (CI)
Glu v pl 51.8% v 34.2% (2) 52% (20 to 91)‡ 6 (4 to 13)‡

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