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Infusion of low dose dopamine did not reduce renal failure in at risk patients in the intensive care unit

https://doi.org/10.1136/ebn.4.4.118

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    Bellomo R, Chapman M, Finfer S, et al. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trial Group.Lancet2000 Dec 23/30;356:2139–43OpenUrlCrossRefPubMedWeb of Science

    QUESTION: Does low dose dopamine decrease the risk of renal failure in at risk patients in the intensive care unit (ICU)?

    Design

    Randomised (allocation concealed), blinded (patients, clinicians, outcome assessors, data analysts), controlled trial with follow up to defined study events.

    Setting

    23 ICUs in Australia, New Zealand, and Hong Kong.

    Patients

    328 patients who had central venous catheters, ≥2 pathophysiological changes of the systemic inflammatory response syndrome (SIRS) over a 24 hour period, and ≥1 indicator of early renal dysfunction (mean urine output <0.5 ml/kg/h over ≥4 h, serum creatinine concentration >150 μmol/l with no premorbid renal dysfunction, increase in serum creatinine concentration of >80 μmol/l in <24 h without creatine kinase >5000 IU/l or myoglobin in the urine). Exclusion criteria were age <18 years, episode of acute renal failure …

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    Footnotes

    • ↵* Information provided by author.

    • Sources of funding: Australian and New Zealand Intensive Care Society and the Austin and Repatriation Anaesthesia and Intensive Care Trust Fund.

    • For correspondence: Mrs A Burger, ANZICS House, 233 Rathdowne Street, Carlton, Victoria 3503, Australia. Fax +61 3 9639 4717.