Evid Based Nurs 4:91 doi:10.1136/ebn.4.3.91
  • Prognosis

Children's adverse reactions to subsequent peanut exposure were often more serious than symptoms experienced in initial reactions

 QUESTION: In young children with peanut allergy, what is the nature and rate of adverse reactions caused by accidental peanut exposure?


Prospective cohort study with a median of 5.9 years (range 1.4–22.4 y) of follow up.


Boulder, Colorado, USA.


102 children with clinical peanut hypersensitivity diagnosed before their fourth birthday. Children were included if they had a convincing history of clinical peanut hypersensitivity, a positive double blind, placebo controlled food challenge response to peanuts, or both; and a positive skin prick test response to peanuts. 83 children (81%) (median age 2.4 y, 69% boys) were included in the analysis.

Assessment of prognostic factors

Severity of symptoms (non-life threatening or potentially life threatening) and organ system involvement (skin, respiratory, gastrointestinal, or other) with symptoms experienced after accidental peanut exposure. Serum peanut specific immunoglobulin E (IgE) concentrations were measured in 51 of 83 (61%) children.

Main outcome measure

Subsequent adverse reactions after …

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