Children's adverse reactions to subsequent peanut exposure were often more serious than symptoms experienced in initial reactions
QUESTION: In young children with peanut allergy, what is the nature and rate of adverse reactions caused by accidental peanut exposure?
Prospective cohort study with a median of 5.9 years (range 1.4–22.4 y) of follow up.
Boulder, Colorado, USA.
102 children with clinical peanut hypersensitivity diagnosed before their fourth birthday. Children were included if they had a convincing history of clinical peanut hypersensitivity, a positive double blind, placebo controlled food challenge response to peanuts, or both; and a positive skin prick test response to peanuts. 83 children (81%) (median age 2.4 y, 69% boys) were included in the analysis.
Assessment of prognostic factors
Severity of symptoms (non-life threatening or potentially life threatening) and organ system involvement (skin, respiratory, gastrointestinal, or other) with symptoms experienced after accidental peanut exposure. Serum peanut specific immunoglobulin E (IgE) concentrations were measured in 51 of 83 (61%) children.
Main outcome measure
Subsequent adverse reactions after …