Evid Based Nurs 4:86 doi:10.1136/ebn.4.3.86
  • Treatment

Aspirin but not vitamin E prevented cardiovascular events in patients at risk

Aspirin v no aspirin and vitamin E v no vitamin E for patients with major cardiovascular risk factors*

Outcomes at mean of 3.6 years Comparison Event rates RRR (95% CI) NNT (CI)
*Combined endpoint = cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Abbreviations defined in glossary; RRR, RRI, NNT, NNH, and CI calculated from data in article.
Combined endpoint Aspirin v no aspirin 2.0% v 2.8% 29% (−4 to 52) Not significant
Cardiovascular death Aspirin v no aspirin 0.8% v 1.4% 44% (1 to 69) 166 (81 to 62500)
Total cardiovascular events Aspirin v no aspirin 6.3% v 8.2% 23% (5 to 38) 53 (30 to 258)
Combined endpoint Vitamin E v no vitamin E 2.5% v 2.3% 7% (−56 to 26) Not significant

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