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Evid Based Nurs 4:47 doi:10.1136/ebn.4.2.47
  • Treatment

Review: NSAIDs, paracetamol, and analgesic/anti-inflammatory oral rinse reduce sore throat symptoms

Non-antibiotic treatments v placebo for sore throat symptoms

Drug Dosage Patients Decrease in throat pain
Ibuprofen 400 mg (1 dose) 80 adults 80% at 4 hours, 70% at 6 hours
400 mg (1 dose) 20 adults 47% at 2 hours
200 mg (1 dose) 18 adults 32% at 2 hours
10 mg/kg (1 dose) 78 children (3.5–12.5 y) 25% at 2 hours, not significant at 6 hours
10 mg/kg 3 times daily for 2 days 153 children (6–12 y) 56% at 2 days
Aspirin 800 mg plus caffeine, 64 mg (1 dose) 139 adults 75% at 1 hour
800 mg (1 dose) 137 adults 55% at 1 hour
Aspirin containing gum 20 men 53% initially, 50% at 2 hours
Niflumic acid 1000 mg/day for 4–5 days 230 adults 17% at 2 days, 33% at 4 days
Paracetamol 1000 mg (1 dose) 81 adults 50% at 3 hours, 20% at 6 hours
15 mg/kg (1 dose) 77 children (3.5–12.5 y) 31% at 2 hours, not significant at 6 hours
10 mg/kg 3 times/day for 2 days 154 children (6–12 y) 34% at 2 days
Oral rinse Benzydamine HCl 0.15% 3 hourly 51 patients (17–74 y) 42% at 3 days

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