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Routine primary immunisation using a longer needle resulted in fewer local reactions in infants

https://doi.org/10.1136/ebn.4.2.41

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    Diggle L, Deeks J.Effect of needle length on incidence of local reactions to routine immunisation in infants aged 4 months: randomised controlled trial.BMJ2000 Oct 14;321:931–3OpenUrlAbstract/FREE Full Text

    QUESTION: When giving routine immunisations to infants, does needle length affect the incidence of local reactions?

    Design

    Randomised (allocation concealed), blinded (outcome assessors), controlled trial with follow up to 3 days.

    Setting

    8 general practices in Buckinghamshire, UK.

    Participants

    119 healthy infants attending routine immunisation clinics. Exclusion criteria were those applicable to children receiving primary immunisations. 92% of infants (58% boys) completed follow up.

    Intervention

    58 infants were allocated to receive their third dose of diphtheria, pertussis, and tetanus and Haemophilus influenzae type b vaccines (due at 16 weeks) given with a 23 gauge, 25 mm (longer) blue hub needle …

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    Footnotes

    • Source of funding: Smith and Nephew Foundation.

    • For correspondence: Ms L Diggle, Oxford Vaccine Group, University Department of Paediatrics, John Radcliffe Hospital, Oxford OX3 9DU, UK. Fax +44 (0)1865 221068.

    • A modified version of this abstract appears in Evidence-Based Medicine.