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Evid Based Nurs 3:123 doi:10.1136/ebn.3.4.123
  • Treatment

Oestrogen plus progestin increased venous thromboembolic disease in postmenopausal women with coronary artery disease

Hormone replacement therapy (HRT) v placebo in postmenopausal women with established coronary artery disease†

Outcomes at mean 4.1 years HRT Placebo RRI (95% CI) NNH (CI)
†Abbreviations defined in glossary; RRI, NNH, and CI calculated from data in article.
Any venous thromboembolic event 2.5% 0.9% 162% (40 to 390) 66 (39 to 172)
Deep venous thrombosis 1.8% 0.7% 178% (33 to 484) 86 (48 to 279)
Non-idiopathic venous thromboembolic event 1.8% 0.7% 151% (23 to 412) 92 (50 to 372)
Pulmonary embolism 0.8% 0.3% 176% (−7 to 718) Not significant
Idiopathic venous thromboembolic event 0.7% 0.2% 201% (−12 to 925) Not significant

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