Evid Based Nurs 3:123 doi:10.1136/ebn.3.4.123
  • Treatment

Oestrogen plus progestin increased venous thromboembolic disease in postmenopausal women with coronary artery disease

 QUESTION: Does oestrogen plus progestin increase the risk of venous thromboembolic events in postmenopausal women with established coronary artery disease (CAD)?


Randomised {allocation concealed}*, blinded (investigators, patients, outcome assessors), placebo controlled trial with mean follow up of 4.1 years (Heart and Estrogen/progestin Replacement Study [HERS]).


20 clinical centres in the US.


2763 postmenopausal women <80 years of age (mean age 67 y, 89% white) with established CAD but no previous venous thromboembolism and who had not had a hysterectomy. Exclusion criteria were CAD event ≤6 months or hormone use ≤3 months before entry, venous thromboembolism, breast cancer, endometrial cancer, uncontrolled hypertension, diabetes, or other fatal disease. Follow up was …

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