Article Text
Treatment
Oestrogen plus progestin increased venous thromboembolic disease in postmenopausal women with coronary artery disease
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QUESTION: Does oestrogen plus progestin increase the risk of venous thromboembolic events in postmenopausal women with established coronary artery disease (CAD)?
Design
Randomised {allocation concealed}*, blinded (investigators, patients, outcome assessors), placebo controlled trial with mean follow up of 4.1 years (Heart and Estrogen/progestin Replacement Study [HERS]).
Setting
20 clinical centres in the US.
Patients
2763 postmenopausal women <80 years of age (mean age 67 y, 89% white) with established CAD but no previous venous thromboembolism and who had not had …