You are here

Article Text

Article menu
Download PDFPDF
Treatment
Supplemental oxygen did not reduce progression of pre-threshold retinopathy of prematurity in infants

https://doi.org/10.1136/ebn.3.4.114

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    The STOP-ROP Multicenter Study Group.Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity (STOP-ROP), a randomized, controlled trial. I: primary outcomes.Pediatrics2000 Feb;105:295–310OpenUrlAbstract/FREE Full Text

    QUESTION: In premature infants, is supplemental oxygen at pulse oximetry saturations of 96% to 99% more effective than conventional oxygen at pulse oximetry saturations of 89% to 94% in reducing the progression from moderate (pre-threshold) to threshold retinopathy of prematurity (ROP)?

    Design

    Randomised (allocation concealed), blinded (outcome assessor), controlled trial with 3 months of follow up.

    Setting

    71 hospitals affiliated with 30 centres in the US.

    Patients

    649 infants (mean gestational age 25 wks, 57% boys, 55% white) who were born prematurely, had pre-threshold ROP in ≥1 eye, and had a median pulse oximetry ≤94% oxygen saturation in room air. Infants were excluded if they had lethal anomalies or congenital anomalies of the eye. Follow up was 92%.

    Intervention

    After stratification by study centre and 2 levels …

    View Full Text

    Footnotes

    • Sources of funding: National Institute of Child Health and Human Development; National Institute of Nursing Research; National Institutes of Health; Delta Gamma Sorority; Rhea and Raymond White Donation; Research to Prevent Blindness; Chartwell Home Therapy; Ohmeda Corporation.

    • For correspondence: Dr D L Phelps, Children's Hospital at Strong, University of Rochester School of Medicine and Dentistry, Pediatrics, Box 651, 601 Elmwood Avenue, Rochester, NY 14642, USA. Fax +1 716 461 3614.

    • ↵* p Value calculated from data in article.