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Lactobacillus GG reduced diarrhoea incidence in antibiotic treated children

https://doi.org/10.1136/ebn.3.3.76

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    Vanderhoof JA, Whitney DB, Antonson DL, et al.Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children.J Pediatr1999 Nov;135:564–8OpenUrlCrossRefPubMedWeb of Science

    QUESTION: In children being treated with antibiotics, does co-administration of Lactobacillus GG (LGG) reduce the incidence of diarrhoea?

    Design

    Randomised (allocation concealed), blinded (clinicians, patients, and outcome assessors), placebo controlled trial with 10 days of follow up.

    Setting

    Primary care paediatric practice in Rapid City, South Dakota, USA.

    Patients

    202 children between 6 months and 10 years of age who had an acute infection of the upper or lower respiratory tract, urinary tract, soft tissues, or skin, and were prescribed a 10 day course of antibiotics. Exclusion criteria were chronic disease, serious acute infection, or diarrhoea at the start of antibiotic administration. 188 children (93%) (median age 4 y, 55% girls) completed the study.

    Intervention

    Children were allocated to LGG (CAG Functional Foods, Omaha, NE, …

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    Footnotes

    • Source of funding: ConAgra, Inc.

    • For correspondence: Dr J A Vanderhoof, University Medical Associates, 985160 NE Medical Center, University of Nebraska, Omaha, NE 68198-5160, USA. Fax +1 402 559 2412.

    • A modified version of this abstract appears in Evidence-Based Medicine.

    • ↵* p Value calculated from data in article.