|Type of cancer||Number of studies||RR (95% CI)||Heterogeneity|
|*Excluding studies that included premenopausal women in the “never used” group. †Significant heterogeneity existed among study results.|
|Colon||18||0.80 (0.74 to 0.86)||p=0.02†|
|13*||0.76 (0.70 to 0.82)||p=0.32|
|Rectal||10||0.81 (0.72 to 0.92)||p=0.03†|
|7*||0.81 (CI not available)||p=0.06†|
Review: postmenopausal hormone replacement therapy is associated with a decreased risk of colorectal cancer
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