Evid Based Nurs 3:50 doi:10.1136/ebn.3.2.50
  • Treatment

Review: allylamines, azoles, undecenoic acid, and tolnaftate are effective for fungal skin infections of the foot

 QUESTION: Are topical treatments effective for fungal infections of the skin and nails of the foot?

Data sources

Studies were identified using Medline (1966 to December 1997), EMBASE/Excerpta Medica (1980 to December 1997), CINAHL (inception to December 1997), Cochrane Controlled Trials Register, Science and Social Science Citation Indexes, CAB–Health, Healthstar, DARE, NHS Economic Evaluation, and EconLit and by scanning bibliographies of relevant and unpublished studies, handsearching journals, and contacting drug companies and experts.

Study selection

Randomised controlled trials were selected if they evaluated topical treatments for mycologically diagnosed fungal infections of the skin and nails of the foot.

Data extraction

Study methodology and quality, participant characteristics, intervention regimens and costs, mycological cure or recurrence, quality of life, and adverse events.

Main results

126 trials were identified and 72 (70 of treatment of skin infections of the foot and …

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