Review: penicillin V is better than placebo and equal to non-penicillins for acute maxillary sinusitis
QUESTION: In adults with acute maxillary sinusitis, which antibiotics lead to higher clinical cure rates?
Studies were identified by searching Medline and EMBASE/Excerpta Medica (to October 1998) with the heading sinusitis and terms for randomised controlled trials, scanning bibliographies of relevant articles, and contacting pharmaceutical companies and experts in the field.
Studies were selected if they were randomised controlled trials (RCTs) that compared an antibiotic with placebo or another class of antibiotic in ≥30 patients who were ≥18 years of age and had a history consistent with acute maxillary sinusitis confirmed by radiography or aspiration.
2 or more reviewers independently extracted data on study characteristics; interventions; study duration; length of follow up; …